Hormone Deficiency Disorders

Several hormone deficiency disorders, where hormone replacement therapy could not
re-establish a normal hormonal balance, have been helped by BCRO fetal cell transplantation with increasing frequency.

Besides diabetes mellitus there are other common hormonal diseases where the endocrine glands function is low, such as hypothyroidism, premature menopause, etc.,
in which BCRO fetal cell transplantation may be necessary in patients who stopped responding properly to the standard hormone replacement therapy.

Although some of these diseases, such as hypothyroidism, are as common as diabetes mellitus, the statistics of its incidence are not too accurate, because hypothyroidism is the cause of death or seriously disabling complications only rarely, and its socio-economic significance is low. It has been observed with increasing frequency nowadays that diseases with low function of endocrine glands respond to the hormone replacement therapy not as well as expected, even in hands of the best endocrinologist.

At the same time physicians have been noticing more and more often that majority  of patients diagnosed with hypothyroidism or Addison disease (with low function of adrenal cortex) etc., developed such illnesses because of autoimmunity. This could explain a lower success rate of a classical hormone replacement therapy in such patients:

  • the relentless progress of an autoimmune damage of hormone producing cells of the diseased endocrine gland ultimately leaves patient with very low quantity of functioning endocrine cells,
  • so that even a high dosage of oral hormone pills cannot provide a patient with an adequate level of missing hormone,
  • but the competitive inhibition whereby the oral hormone therapy suppresses the function of patient’s own cells producing the same hormone may play a part.

In such instances endocrinologists have been turning to BCRO fetal cell transplantation more and more often.

The goal of BCRO fetal cell transplantation in the treatment of such autoimmune diseases is:

  • mostly immunomodulation, i.e. normalization of immune system function, and thereby suppression of the autoimmune process, and
  • a repair, or regeneration, of non-functioning hormone producing cells.

It is not a purpose of cell therapy to eliminate the need for hormone replacement therapy.

BCRO fetal cell transplantation should aim at balancing regulations of the ‘axis hypothalamus – pituitary – peripheral endocrine gland (thyroid in hypothyroidism)’, disturbed by years of disharmony and demands for over-compensation.

Level of hormones has to be measured after cell transplantation much more frequently, and the dosage of oral hormones lowered accordingly, but as a rule their intake cannot be discontinued. If we disregard diabetes mellitus, among hormone deficiency disorders the most common indication for BCRO cell transplantation in clinical practice has been a pronounced hypothyroidism, which is practically always a result of Hashimoto’s
(autoimmune) thyroiditis.

Overall the numbers of patients with hypothyroidism so treated have not been high,
and clinical reports have been but a few. The treatment of hormonal diseases with low functioning sex glands is discussed elsewhere.